Cefoperazone concentrations in bile and gall bladder wall after intravenous administration

Area of Science:

• Pharmacokinetics
• Surgical Infections

Background:

• Cefoperazone is a third-generation cephalosporin antibiotic.
• Understanding drug penetration into biliary tissues is crucial for treating infections in this area.

Purpose of the Study:

• To quantify cefoperazone concentrations in common duct bile, gallbladder bile, and gallbladder wall.
• To assess the penetration of cefoperazone into biliary tissues in patients with normal renal function.

Main Methods:

• Four patients with cholelithiasis and one with pancreatic carcinoma underwent intravenous administration of 1g cefoperazone.
• Bile and gallbladder wall samples were collected and analyzed for cefoperazone concentrations.

Main Results:

• Maximum common duct bile concentrations ranged from 373.4 to 3,100 µg/ml.
• Gallbladder bile concentrations ranged from 6.8 to 680 µg/ml.
• Gallbladder wall concentrations ranged from 16.8 to 48.0 µg/g.

Conclusions:

• Cefoperazone achieves significant concentrations in bile and gallbladder tissue.
• These findings support the use of cefoperazone for treating biliary tract infections.