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Suppressor lymphocytes during open heart surgery
Open heart surgery is associated with a moderate to severe postoperative of cell-mediated immunity. To characterize this defect, T-suppressor lymphocytes were studied in nine patients undergoing elective aortic/mitral valve replacement surgery. A decrease of the number of T-suppressor lymphocytes was observed after the operation. At the same time the activity of concanavalin A (Con A)- and phytohaemagglutinin (PHA)-induced suppressor cells decrease. Thus the decrease of cell-mediated immunity after open heart surgery seems not to be due to activation of suppressor lymphocytes.
Open heart surgery is associated with a moderate to severe postoperative of cell-mediated immunity. To characterize this defect, T-suppressor lymphocytes were studied in nine patients undergoing elective aortic/mitral valve replacement surgery. A decrease of the number of T-suppressor lymphocytes was observed after the operation. At the same time the activity of concanavalin A (Con A)- and phytohaemagglutinin (PHA)-induced suppressor cells decrease. Thus the decrease of cell-mediated immunity after open heart surgery seems not to be due to activation of suppressor lymphocytes.