Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suppressor lymphocytes during open heart surgery.

M Salo, E Soppi, O Lassila

    Journal of Clinical & Laboratory Immunology
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nationwide paediatric cohort study of a protective association between allergy and complicated appendicitis.

    The British journal of surgery·2021
    Same author

    Nationwide study of appendicitis in children.

    The British journal of surgery·2019
    Same author

    BLIMP-1 is insufficient to induce antibody secretion in the absence of IRF4 in DT40 cells.

    Scandinavian journal of immunology·2018
    Same author

    IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses.

    Scandinavian journal of immunology·2015
    Same author

    Regulation of B Cell to Plasma Cell Transition within the Follicular B Cell Response.

    Scandinavian journal of immunology·2015
    Same author

    Mug handle affordance and automatic response inhibition: behavioural and electrophysiological evidence.

    Quarterly journal of experimental psychology (2006)·2013
    Same journal

    Policy and science of FMD control: the stakeholders' contribution to decision making. A call for integrated animal disease management.

    Journal of clinical & laboratory immunology·2006
    Same journal

    An informative case of Graves' disease with implications for schizophrenia.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Increase of circulating CD8+CD57+ lymphocytes after measles infection but not after measles vaccination.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Review: immunomodulatory activity of pregnancy-associated plasma protein-A.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Antibodies to Acinetobacter bacteria and bovine brain peptides, measured in bovine spongiform encephalopathy (BSE) in an attempt to develop an ante-mortem test.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Principles of autoimmune disease: pathogenesis, genetics and specific immunotherapy.

    Journal of clinical & laboratory immunology·2004
    See all related articles

    Open heart surgery impairs cell-mediated immunity. Studies show a decrease in T-suppressor lymphocytes and their activity post-operation, suggesting this defect is not caused by suppressor cell activation.

    Area of Science:

    • Immunology
    • Surgical Science

    Background:

    • Open heart surgery can lead to significant postoperative impairment of cell-mediated immunity.
    • Understanding the mechanisms behind this immune defect is crucial for patient recovery.

    Purpose of the Study:

    • To investigate the role of T-suppressor lymphocytes in the cell-mediated immunity defect following open heart surgery.
    • To determine if an increase in suppressor lymphocyte activity contributes to postoperative immunosuppression.

    Main Methods:

    • Studied nine patients undergoing elective aortic/mitral valve replacement.
    • Monitored the number and activity of T-suppressor lymphocytes before and after surgery.
    • Assessed the activity of concanavalin A (Con A) and phytohaemagglutinin (PHA)-induced suppressor cells.

    Related Experiment Videos

    Main Results:

    • A decrease in the number of T-suppressor lymphocytes was observed post-operation.
    • The activity of Con A- and PHA-induced suppressor cells also decreased after surgery.
    • These findings indicate a reduction, not an activation, of suppressor cell function.

    Conclusions:

    • The postoperative decrease in cell-mediated immunity after open heart surgery is not attributed to an activation of suppressor lymphocytes.
    • The observed reduction in T-suppressor lymphocytes and their activity may play a role in the immune deficit.