Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T cell growth factor abrogates concanavalin A-induced suppressor cell function.

R Palacios, G Möller

    The Journal of Experimental Medicine
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Machine learning approach to muon spectroscopy analysis.

    Journal of physics. Condensed matter : an Institute of Physics journal·2021
    Same author

    The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: a PREVIEW sub-study.

    European journal of nutrition·2019
    Same author

    Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
    Same author

    B lymphocyte activation.

    Immunology today·2014
    Same author

    Majorana modes and p-wave superfluids for fermionic atoms in optical lattices.

    Nature communications·2014
    Same author

    A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding.

    Allergy·2014
    Same journal

    Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

    The Journal of experimental medicine·2026
    Same journal

    Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

    The Journal of experimental medicine·2026
    Same journal

    Flawed translation triggers oncogenic B-T cell communication.

    The Journal of experimental medicine·2026
    Same journal

    Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

    The Journal of experimental medicine·2026
    Same journal

    Mechanobiology of inflammation: Pulling the strings of innate immunity.

    The Journal of experimental medicine·2026
    Same journal

    Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

    The Journal of experimental medicine·2026
    See all related articles

    Concanavalin A (Con-A)-induced suppressor T cells reduce T cell growth factor (TCGF) levels. Cyclosporin-A (CYA) inhibits suppressor T cell activity by blocking TCGF receptors.

    Area of Science:

    • Immunology
    • Cellular Biology

    Background:

    • Suppressor T cells play a critical role in immune regulation.
    • T cell growth factor (TCGF) is essential for T cell proliferation and function.

    Purpose of the Study:

    • To investigate the mechanism by which Concanavalin A (Con-A)-induced suppressor T cells exert their function.
    • To determine the role of T cell growth factor (TCGF) in suppressor T cell activity.
    • To elucidate the effect of Cyclosporin-A (CYA) on suppressor T cell function.

    Main Methods:

    • Induction of suppressor T cells using Concanavalin A (Con-A).
    • Assessing suppressor T cell activity on lymphocyte proliferation (PHA and alloantigen) and immunoglobulin secretion (PWM).
    • Evaluating the effect of TCGF and CYA on suppressor T cell activity and TCGF absorption.

    Related Experiment Videos

  • Measuring DNA synthesis and immunoglobulin synthesis as indicators of immune response.

    • Main Results:

    • Con-A-induced suppressor T cells proliferate in response to TCGF.
    • TCGF abrogates the suppressor activity of these cells on lymphocyte proliferation and immunoglobulin secretion.
    • Suppressor T cells absorb TCGF, and preincubation with TCGF abolishes their suppressor activity.
    • CYA inhibits suppressor T cell activity by blocking TCGF receptors, making cells unresponsive to TCGF.

    Conclusions:

    • Con-A-induced suppressor T cells function by decreasing available TCGF levels.
    • CYA abrogates Con-A-induced suppressor T cell function by inhibiting TCGF receptor expression on T cells.