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Immuno electron microscopic studies on cells synthesizing elastin.

V Damiano, A Tsang, U Kucich

    Connective Tissue Research
    |January 1, 1981
    PubMed
    Summary
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    Researchers found that elastin, a key protein in blood vessels, is secreted by cells through tiny sacs called vesicles. This process was observed in both chick and hamster embryonic aortas, suggesting a common mechanism for elastin secretion.

    Area of Science:

    • Vascular biology
    • Cell biology
    • Extracellular matrix research

    Background:

    • Elastin is a crucial component of the extracellular matrix, providing elasticity to blood vessels.
    • The precise mechanism of elastin secretion by cells has been a subject of ongoing research.

    Purpose of the Study:

    • To investigate the cellular mechanisms of elastin secretion in embryonic aortas.
    • To identify the cellular structures involved in elastin transport and release.

    Main Methods:

    • Electron microscopy was used to examine embryonic chick and hamster aortas.
    • Ferritin-conjugated, elastin-specific antibodies were employed for precise labeling.
    • Sections were etched with a benzene, methanol, and ethanol solution to enhance visualization.

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    Main Results:

    • Specific ferritin staining indicated the presence of elastin within intracellular vesicles in both smooth muscle and endothelial cells.
    • These vesicles appeared to fuse with the plasma membrane.
    • Evidence suggests the discharge of elastin-containing vesicles into the extracellular space.

    Conclusions:

    • Elastin secretion in embryonic aortas occurs via vesicular transport.
    • Intracellular vesicles fuse with the plasma membrane to release elastin into the extracellular matrix.
    • This finding provides insight into the biogenesis of elastic fibers in developing blood vessels.