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Failure to interrupt established pregnancy in humans by D-tryptophan-6-luteinizing hormone-releasing hormone
Fertility and Sterility
|August 1, 1981
Abstract:
Four women 5 to 8 weeks into pregnancy, scheduled for therapeutic abortions, were given an analog of gonadotropin-releasing hormone, D-tryptophan-6-LHRH, in an effort to interrupt pregnancy. The treatment consisted of 100-micrograms injections, given twice daily for 5 to 10 days. No decline in serum beta-hCG or progesterone was noted, and menstrual extraction was needed in all women for pregnancy interruption. These data indicate that D-Trp-6-LHRH is not effective as an abortifacient in established pregnancy.
Keywords:
Abortion, Drug InducedAbortion, InducedBiologyClinical ResearchEndocrine SystemFamily PlanningFertility Control, PostconceptionGonadotropinsGonadotropins, Chorionic--analysisHormonesPhysiologyPituitary Hormone Releasing Hormones--administraction and dosagePituitary HormonesPregnancyPregnancy, First TrimesterProgestational HormonesProgesterone--analysisProlactin--analysisReproductionResearch Methodology