[Effect of epidermal chalones on cell proliferation in regenerating epidermis]

The data on the kinetic analysis of epidermocyte proliferation after hair plucking earlier reported elsewhere (Ketlinsky 1980), were used for studying the epidermal chalone action on the interfollicular epidermis regeneration. In two series of experiments, G1-S inhibitory effect of epidermal chalones has been studied. Chalones were injected in various periods of time after plucking, and their effect was registered within 15 hours. The inhibitory effect of chalones was shown to occur, if they were injected at the first six hours after plucking. Chalones injection 15 hours after operation, when the second epidermocyte population had entered into proliferation, preserved the development of epidermis hyperplasis. The highest inhibitory action of chalones on epidermocyte proliferation occurred, if they were injected just before the operation. In this case, the induction of proliferation was not revealed for up to 25 hours after plucking. It is proposed that chalones may play an important role in the non-specific resistance of the cell.