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Mezlocillin: tentative interpretive standards for disk diffusion susceptibility testing.

P C Fuchs, A L Barry, C Thornsberry

    Antimicrobial Agents and Chemotherapy
    |August 1, 1981
    PubMed
    Summary
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    New interpretive criteria for mezlocillin disk susceptibility testing are proposed for bacterial isolates. These guidelines aid in determining bacterial resistance or susceptibility to mezlocillin and carbenicillin, crucial for effective antibiotic treatment.

    Area of Science:

    • Microbiology
    • Clinical Bacteriology
    • Antimicrobial Susceptibility Testing

    Background:

    • Accurate antimicrobial susceptibility testing (AST) is essential for guiding effective antibiotic therapy.
    • Mezlocillin and carbenicillin are important beta-lactam antibiotics used to treat bacterial infections.
    • Standardized interpretive criteria are necessary for reliable AST results.

    Purpose of the Study:

    • To evaluate the susceptibility of clinical bacterial isolates to mezlocillin and carbenicillin.
    • To propose tentative interpretive criteria for disk diffusion susceptibility testing of mezlocillin.
    • To compare the efficacy of disk diffusion and broth micro-dilution methods for AST.

    Main Methods:

    • Testing of 447 clinical bacterial isolates.

    Related Experiment Videos

  • Standardized agar disk diffusion method.
  • Reference broth micro-dilution method.

    • Main Results:

    • Tentative interpretive criteria for 75 mcg mezlocillin disks proposed: susceptible (≥16 mm), indeterminate (13-15 mm), resistant (≤12 mm).
    • Proposed criteria applicable to Pseudomonas species and Enterobacteriaceae.
    • Distinct criteria established for Staphylococcus aureus susceptibility to mezlocillin.

    Conclusions:

    • The proposed interpretive criteria facilitate accurate disk diffusion testing for mezlocillin.
    • These criteria aid in differentiating susceptible, indeterminate, and resistant bacterial strains.
    • AST results guide appropriate antibiotic selection for patient treatment.