[Local and general immunity in diseases of the nervous system]

In normal condition, the nervous system has no local immunity, and general immunity is here very poor. However, in many neuro-immunological diseases, a local immunity appears, i.e.: a local synthesis of immunoglobulins. General immunity may be increased by transudation of blood components into CSF, either separately (inflammatory transudate) or simultaneously (meningitis) with this local synthesis. A mathematical formula is proposed is useful for some reasons: 1) evaluation of local immunity; 2) definition of CSF immunological patterns into 5 types and a neuro-immunological classification of neurological diseases; 3) research of the etiology in some nervous disease; 4) objective analysis of results of immunotherapy. Multiple sclerosis gives a good example of this 4 points of interest.