Related Experiment Videos
Cefoperazone: spectrum of antibacterial activity and disc diffusion testing.
Drugs
|January 1, 1981
Summary
Cefoperazone exhibits broad-spectrum antibacterial activity against numerous pathogens, including Pseudomonas aeruginosa and beta-lactamase positive strains. This new cephalosporin demonstrates high efficacy in inhibiting most clinical isolates, supporting its use in clinical settings.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Cefoperazone is a novel cephalosporin antibiotic.
- It possesses a broad spectrum of antibacterial activity.
Purpose of the Study:
- To evaluate the in vitro antibacterial spectrum and activity of cefoperazone.
- To establish susceptibility testing breakpoints for cefoperazone.
Main Methods:
- Testing of over 8700 clinical bacterial isolates against cefoperazone.
- Determination of minimum inhibitory concentrations (MICs).
- Evaluation of diffusion test disc potency and breakpoints.
Main Results:
- Cefoperazone inhibited approximately 93% of isolates at 16 µg/ml, 95% at 32 µg/ml, and 98% at 64 µg/ml.
- The drug showed broad activity against Enterobacteriaceae, Pseudomonas aeruginosa, staphylococci, Neisseria, Haemophilus, and some anaerobes.
- Lower activity was observed against Acinetobacter and group D streptococci.
Conclusions:
- Cefoperazone demonstrates potent in vitro activity against a wide range of clinically significant bacteria.
- Recommended breakpoints for cefoperazone diffusion tests are provided: ≤14 mm (resistant), 15-17 mm (intermediate), ≥18 mm (susceptible).