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Enteric fever: a clinicopathologic study of 104 cases
The American Journal of Gastroenterology
|January 1, 1978
Summary
This study on enteric fever found fever and bradycardia are key signs, with typhoid hepatitis and anemia being common complications. Disseminated intravascular coagulation is a rare but serious risk.
Area of Science:
- Infectious Diseases
- Hepatology
- Pathology
Background:
- Enteric fever, a systemic infection, presents with diverse clinical manifestations and potential complications.
- Understanding the clinical, laboratory, and pathological features is crucial for effective patient management.
Observation:
- A review of 104 patients with culture-proven enteric fever identified fever and bradycardia as leading signs.
- Splenomegaly, hepatomegaly, and rose spots were also noted clinical findings.
- Complications included anemia, typhoid hepatitis (30% of tested patients), relapse, and bleeding.
Findings:
- Pathological examination revealed typhoid nodules, varying in size and frequency with disease severity.
- A significant association was observed between typhoid hepatitis and disease relapse, with 4 of 7 relapsed patients showing abnormal liver tests.
- Disseminated intravascular coagulation was a rare but fatal complication in one presented case.
Implications:
- Early recognition of clinical signs and prompt management of complications like typhoid hepatitis can improve patient outcomes.
- Awareness of rare but severe complications, such as disseminated intravascular coagulation, is vital for potentially life-saving interventions.
- Further research into the pathogenesis of typhoid hepatitis and its link to relapse may offer new therapeutic targets.