Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacological studies on serotonin-mediated behaviour.

A R Green

    Journal De Physiologie
    |January 1, 1981
    PubMed
    Summary

    Monoamine oxidase inhibitor and L-tryptophan administration in rats increases serotonin (5-HT) synthesis and release, causing behavioral changes. Specific 5-HT antagonists differentially inhibited these behaviors, suggesting distinct receptor populations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biology of primary breast cancer in older women beyond routine biomarkers.

    Breast cancer (Tokyo, Japan)·2021
    Same author

    Correction to: KSR1 regulates BRCA1 degradation and inhibits breast cancer growth.

    Oncogene·2021
    Same author

    Patterns of biomarker expression in patients treated with primary endocrine therapy - a unique insight using core needle biopsy tissue microarray.

    Breast cancer research and treatment·2020
    Same author

    The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial.

    Trials·2020
    Same author

    The Use of Figurative Language to Describe Frailty in Older Adults.

    The Journal of frailty & aging·2018
    Same author

    The significance of tumour microarchitectural features in breast cancer prognosis: a digital image analysis.

    Breast cancer research : BCR·2018

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Monoamine oxidase inhibitors (MAOIs) and L-tryptophan administration increase serotonin (5-HT) synthesis and release in rats.
    • This leads to observable behavioral changes, some quantifiable via activity meters.
    • Previous research indicated potential roles for dopamine and GABA in these behaviors.

    Purpose of the Study:

    • To investigate the neurochemical mechanisms underlying 5-HT-mediated behaviors.
    • To determine the involvement of different neurotransmitter systems, particularly serotonin receptors.
    • To explore the differential effects of various 5-HT antagonists on specific behaviors.

    Main Methods:

    • Administration of tranylcypromine (MAOI) followed by L-tryptophan to rats.
    • Utilized specific lesioning techniques and p-chlorophenylalanine pretreatment to induce supersensitive responses.
    • Administered various putative 5-HT agonists, releasing drugs, and antagonists, including methysergide, methergoline, (--)-propranolol, cinanserin, mianserin, and quipazine.

    Main Results:

    • Tranylcypromine/L-tryptophan and 5-methoxy N,N-dimethyl tryptamine induced behaviors were inhibited by some, but not all, putative 5-HT antagonists.
    • Specific antagonists like methysergide, methergoline, and (--)-propranolol showed inhibitory effects.
    • All tested antagonists inhibited behaviors induced by the direct agonist quipazine.

    Conclusions:

    • The differential effects of antagonists suggest the involvement of distinct serotonin receptor populations mediating these behaviors.
    • The findings highlight the complexity of 5-HT receptor signaling in behavioral responses.
    • Further research into receptor binding characteristics is warranted to fully elucidate these mechanisms.

    Related Experiment Videos