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[Intravenous injection of synthetic oxytocin induces a decrease of cortisol plasma level in normal man].

P Chiodera, J J Legros

    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1981
    PubMed
    Summary

    Synthetic oxytocin (Oxy) significantly reduced plasma cortisol levels in healthy volunteers compared to saline. This suggests oxytocin influences the body's stress hormone regulation.

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    Area of Science:

    • Endocrinology
    • Neuroendocrinology

    Context:

    • The hypothalamic-pituitary-adrenal (HPA) axis regulates cortisol release, a key stress hormone.
    • Oxytocin, a neuropeptide hormone, is known for its roles in social bonding and reproduction, but its influence on the HPA axis is less understood.

    Purpose:

    • To investigate the effect of synthetic oxytocin administration on plasma cortisol levels in healthy human volunteers.
    • To compare the cortisol response to oxytocin versus a saline placebo using a double-blind, cross-over design.

    Summary:

    • Six healthy volunteers received intravenous injections of either synthetic oxytocin (2 IU) or saline in a randomized, blinded, cross-over manner.
    • Plasma cortisol levels were measured before and up to 120 minutes after injection.
    • A significant decrease in plasma cortisol was observed from 45 minutes onwards in the oxytocin group compared to the saline group.

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    Impact:

    • Oxytocin administration leads to a notable reduction in plasma cortisol levels, indicating a suppressive effect on the HPA axis.
    • The findings suggest a direct or indirect action of oxytocin or its metabolites on corticotroph cells or proopiomelanocorticotropic function.
    • Further research is warranted to elucidate the precise mechanism underlying oxytocin's influence on cortisol regulation.