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Piperacillin Sodium (a phase III clinical trial).
The Journal of International Medical Research
|January 1, 1981
Summary
Piperacillin Sodium demonstrated good clinical response in most patients with serious infections. Microbiological cure was achieved in nine patients, with only one adverse event reported.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Microbiology
Background:
- Intravenous antibiotics are crucial for treating severe bacterial infections.
- Piperacillin Sodium is a broad-spectrum penicillin antibiotic used to combat various pathogens.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of Piperacillin Sodium in patients with diverse infections.
- To assess the microbiological response to Piperacillin Sodium treatment.
Main Methods:
- A study involving twenty-one patients with various clinical infections.
- Intravenous administration of Piperacillin Sodium.
- Clinical and microbiological assessments of treatment response.
Main Results:
- Good clinical response was observed in the majority of patients.
- Nine patients achieved microbiological cure.
- One case was a therapeutic failure, and two were unevaluable due to unidentified pathogens.
- A single adverse event, thrombo-phlebitis, was noted.
Conclusions:
- Piperacillin Sodium is effective for treating a range of infections, with a favorable clinical outcome in most cases.
- The antibiotic is well-tolerated, with a low incidence of adverse events.
- Further investigation may be warranted for non-responsive or unevaluable cases.