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Related Experiment Videos

lambda Repressor and cro--components of an efficient molecular switch.

A D Johnson, A R Poteete, G Lauer

    Nature
    |November 19, 1981
    PubMed
    Summary
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    Bacteriophage lambda efficiently switches genes on using a tripartite operator and regulatory proteins. This DNA-protein interaction strategy enables rapid state changes in response to signals.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Virology

    Background:

    • In a lysogen, bacteriophage lambda genes are typically repressed.
    • Phage lambda can be induced to switch gene expression on in response to specific signals.

    Purpose of the Study:

    • To elucidate the mechanism of efficient gene switching in bacteriophage lambda.
    • To understand the role of DNA-protein interactions in regulating phage gene expression.

    Main Methods:

    • Analysis of the tripartite operator in phage lambda.
    • Investigating the binding of regulatory proteins to the operator.
    • Studying signal-mediated transmission effects between DNA-bound proteins.

    Main Results:

    • The gene switching mechanism involves a tripartite operator and two regulatory proteins.

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  • Both DNA-protein interactions and transmitted effects between proteins are crucial.
  • Phage lambda employs an efficient strategy for switching between physiological states.

    • Conclusions:

    • Phage lambda utilizes a sophisticated regulatory system for rapid gene expression changes.
    • The interplay between DNA, proteins, and signal transduction is key to lysogenic control.
    • This system exemplifies efficient biological switching mechanisms.