Blood glucose and pancreatic islets in frogs afer streptozotocin treatment

As to alloxan, the frog Rana tigrina was found to be sensitive to streptozotocin also. An intravenous injection of 200 mg/kg body weight streptozotocin caused a delayed hyperglycemia which returned to normal levels after 120 hrs of the injection. The beta-cells of the endocrine pancreas underwent degranulation and necrosis and the hyperglycemia seems to be due to the deficiency of insulin. There was no visible effect on the alpha-cells, however. Unlike alloxan, streptozotocin did not induce nephrotoxicity in frogs.