Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunocompetence and malignant lymphoma: immunologic status before therapy.

T C Anderson, S E Jones, B J Soehnlen

    Cancer
    |December 15, 1981
    PubMed
    Summary

    Malignant lymphoma patients exhibit a spectrum of B and T cell immunodeficiencies that correlate with disease type and stage. This impacts immune function, affecting lymphocyte counts and skin test reactivity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ovarian function suppression decision-making and uptake in premenopausal women with breast cancer: a mixed methods analysis.

    Breast cancer research and treatment·2026
    Same author

    COVID-19 and Pregnancy: A Prospective Descriptive Study from a Tertiary Hospital in Nigeria.

    West African journal of medicine·2021
    Same author

    Shifts in learning assistants' self-determination due to COVID-19 disruptions in Calculus II course delivery.

    International journal of STEM education·2021
    Same author

    Progesterone signaling during pregnancy in the lab opossum, Monodelphis domestica.

    Theriogenology·2019
    Same author

    Cross-sectional study of the prevalence, causes and management of hospital-onset diarrhoea.

    The Journal of hospital infection·2019
    Same author

    Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach.

    The Journal of antimicrobial chemotherapy·2017

    Area of Science:

    • Immunology
    • Oncology
    • Hematology

    Background:

    • Malignant lymphoma can affect the immune system.
    • Understanding immunocompetence in lymphoma patients is crucial for prognosis and treatment.

    Purpose of the Study:

    • To evaluate the immunocompetence of previously untreated malignant lymphoma patients.
    • To correlate immune function with lymphoma histology, stage, and clinical features.

    Main Methods:

    • Assessed immune function using tests for lymphocytes, T cells (E-rosettes), B cells (EAC-rosettes), delayed hypersensitivity, immunoglobulins, mixed lymphocyte culture, and mitogen response.
    • Correlated immune test results with patient histology, disease stage, and clinical characteristics.

    Main Results:

    Related Experiment Videos

    • Diffuse lymphomas, particularly diffuse histiocytic (large cell) lymphoma, showed reduced lymphocytes and T cells.
    • Skin test reactivity varied significantly with lymphoma histology and stage.
    • Nodular lymphoma patients had decreased IgA and IgG, while diffuse lymphoma patients had decreased IgA.
    • Lymphocyte mitogen stimulation was depressed across all patient groups.

    Conclusions:

    • A spectrum of B and T cell immunodeficiency exists in malignant lymphoma patients.
    • The degree of immunodeficiency correlates with specific lymphoma histology and disease stage.
    • These findings highlight the complex interplay between lymphoma and immune system function.