Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac output changes during neonatal growth.

J R Woods, A Dandavino, C R Brinkman

    The American Journal of Physiology
    |May 11, 1978
    PubMed
    Summary

    Neonatal lambs show increasing cardiac output (CO) and stroke volume (SV) with growth, but these metrics decrease per unit of body weight. Autonomic stimulation significantly impacts neonatal cardiovascular function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Modern theory of tuberculosis: culturomic analysis of its historical origin in Europe and North America.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2018
    Same author

    Effects of interpolating a secondary task during the intertrial interval of a concept identification problem.

    Memory & cognition·2013
    Same author

    [Not Available].

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Early prediction of cardiac allograft vasculopathy and heart transplant failure.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
    Same author

    Some aspects of endometrial cancer; Its association with pregnancy.

    Obstetricia y ginecologia latino-americanas·2010
    Same author

    Fetal and maternal mortality; an 11-year survey.

    American journal of obstetrics and gynecology·2010

    Area of Science:

    • Cardiovascular Physiology
    • Neonatal Development
    • Comparative Physiology

    Background:

    • Understanding neonatal cardiovascular adaptation is crucial for assessing health and development.
    • Resting cardiac output (CO), stroke volume (SV), and systemic vascular resistance (SVR) are key indicators of cardiovascular function.
    • Neonatal physiological parameters differ significantly from adult values, necessitating specific reference ranges.

    Purpose of the Study:

    • To investigate changes in resting cardiac output (CO), stroke volume (SV), and systemic vascular resistance (SVR) during neonatal growth in lambs.
    • To compare neonatal cardiovascular parameters with adult sheep values.
    • To examine neonatal responses to autonomic agonists and antagonists.

    Main Methods:

    • Chronically instrumented lambs were studied from 1 to 5 weeks of age.
    • Adult nonpregnant sheep values were used as a reference standard.
    • Neonatal responses to beta-adrenergic stimulation and blockade, as well as cholinergic blockade, were assessed.

    Main Results:

    • Total CO increased linearly with neonatal growth but decreased significantly per unit of body weight.
    • Stroke volume (SV) increased with growth and remained higher per kilogram in 5-week-old lambs compared to adults.
    • Systemic vascular resistance (SVR) changed reciprocally to CO, and heart rate (HR) decreased progressively with growth.
    • Beta-receptor stimulation markedly increased neonatal CO, with consistent effects across the studied weeks.
    • Cholinergic blockade produced moderate increases in CO.

    Conclusions:

    • Neonatal lambs exhibit distinct cardiovascular adaptations during growth, with higher CO and SV per unit weight than adults.
    • Heart rate (HR) plays a significant role in the decline of CO per kilogram during neonatal development.
    • The neonatal cardiovascular system demonstrates responsiveness to autonomic stimulation, particularly beta-adrenergic pathways.

    Related Experiment Videos