Serum globulin changes in patients with craniocerebral trauma

Area of Science:

• Biochemistry
• Neurology
• Clinical Medicine

Background:

• Craniocerebral trauma can lead to complex physiological changes.
• Serum protein profiles are often altered following severe head injuries.

Purpose of the Study:

• To investigate alterations in serum protein fractions in patients with craniocerebral trauma.
• To correlate these changes with the severity of brain tissue lesions and patient prognosis.

Main Methods:

• Analysis of serum total protein, albumin, and globulin fractions (alpha-1, alpha-2, alpha-2M, beta, gamma).
• Study involved 48 patients diagnosed with craniocerebral trauma.
• Correlation of protein levels with lesion extent and patient outcomes.

Main Results:

• Alpha-2 globulin significantly increased (average 112%), directly correlating with lesion size.
• Alpha-2M globulin exhibited irregular changes, often decreasing in patients with poor prognoses.
• Alpha-1 globulin showed a less pronounced increase, while gamma globulin tended to decrease in the first week.

Conclusions:

• Serum alpha-2 globulin levels serve as a potential indicator of craniocerebral injury severity.
• Alpha-2M globulin dynamics may offer prognostic insights, though further investigation is needed.
• Specific globulin fraction changes highlight the systemic impact of traumatic brain injury.