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Abnormal histamine-induced suppressor-cell function in atopic subjects.

D J Beer, M E Osband, R P McCaffrey

    The New England Journal of Medicine
    |February 25, 1982
    PubMed
    Summary
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    Atopic subjects exhibit impaired histamine-induced suppressor T-cell activity and fewer histamine Type 2 receptors. This defect in immune regulation is linked to reduced histamine Type 2 receptor expression on T cells.

    Area of Science:

    • Immunology
    • Allergy Research
    • Cellular Immunology

    Background:

    • Atopic individuals may have immunoregulatory defects.
    • Histamine plays a role in immune responses.
    • T-cell receptor expression can be altered in allergic conditions.

    Purpose of the Study:

    • To investigate potential defects in immunoregulatory function in atopic subjects.
    • To examine histamine-induced suppressor-T-cell activity and histamine receptor expression on T cells.

    Main Methods:

    • Studied peripheral-blood mononuclear cells from 16 atopic subjects and 20 nonatopic controls.
    • Assessed histamine-induced suppressor activity.
    • Quantified histamine Type 1 and Type 2 receptors on T lymphocytes.

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    Main Results:

    • Atopic subjects showed significantly less histamine-induced suppressor activity compared to controls (P < 0.005).
    • A lower percentage of T lymphocytes with histamine Type 2 receptors was observed in atopic individuals (P < 0.001).
    • Histamine-induced suppressor cell abnormality correlated with decreased histamine Type 2 receptor expression.

    Conclusions:

    • Atopic subjects have a functional defect in histamine-induced suppressor T-cell activity.
    • Reduced expression of histamine Type 2 receptors on T cells contributes to this immunoregulatory defect.
    • The findings suggest a specific impairment in histamine-mediated immune regulation in atopy.