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Intradermal test with histamine in Schistosomiasis mansoni
The American Journal of Tropical Medicine and Hygiene
|March 1, 1978
Summary
Boys and men with schistosomiasis mansoni showed similar skin reactions to histamine diphosphate injections. This indicates age does not significantly affect histamine-induced skin responses in this patient group.
Area of Science:
- Immunology
- Dermatology
- Parasitology
Background:
- Schistosomiasis mansoni affects millions globally, impacting immune responses.
- Understanding age-related differences in skin reactivity is crucial for diagnostic accuracy.
Purpose of the Study:
- To investigate age-related differences in histamine-induced skin reactions in individuals with schistosomiasis mansoni.
- To compare the skin wheal response to histamine diphosphate between boys and adult men with active schistosomiasis.
Main Methods:
- Intradermal injections of histamine diphosphate at varying dilutions (10^-3, 10^-4, 10^-5) were administered to 25 boys (10-12 years) and 25 men (20-30 years) with schistosomiasis mansoni.
- The mean area of resulting skin wheals was measured and analyzed.
- Linear regression analysis was used to determine the relationship between histamine concentration and wheal area.
Main Results:
- A significant linear relationship was observed between the logarithm of histamine concentrations and the mean wheal area in both boys and men (P < 0.05).
- No significant difference was found in the regression coefficients between the boys' and men's groups.
- This contrasts with previous findings using Schistosoma mansoni antigens, where men showed a greater skin response than boys.
Conclusions:
- Histamine-induced skin reactivity does not differ significantly between prepubertal boys and adult men with active schistosomiasis mansoni.
- The study suggests that age-related differences in skin responses to parasitic antigens may not extend to histamine-induced reactions.