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[Uveitis: a rational diagnostic program for practice in internal medicine].

D Conen, U Schwarz

    Schweizerische Medizinische Wochenschrift
    |January 2, 1982
    PubMed
    Summary
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    Uveitis is a sign of underlying disorders, not a disease itself. A thorough investigation including history, systemic exam, and specific tests is crucial for diagnosis, though 64% of cases remained idiopathic in this study.

    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Infectious Diseases

    Context:

    • Uveitis, an inflammation of the eye's middle layer, often indicates a broader systemic condition.
    • Diagnosis requires more than an ocular examination, considering geographic, environmental, and genetic factors.
    • Potential causes include infectious, allergic, and autoimmune processes.

    Purpose:

    • To establish an effective investigative program for uveitis patients.
    • To identify underlying causes and associated systemic diseases.
    • To determine the utility of a minimal diagnostic workup.

    Summary:

    • A prospective study examined 39 uveitis patients, collecting detailed histories, performing systemic examinations, and conducting various laboratory and imaging tests.

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  • Identified causes included toxoplasmosis, Behçet's disease, sarcoidosis, ankylosing spondylitis, and ulcerative colitis.
  • Despite a comprehensive approach, 64% of patients had no identifiable underlying disorder, highlighting diagnostic challenges.

    • Impact:

    • Recommends a minimal diagnostic program including detailed history, systemic examination, blood tests (BSR, CBC), tuberculin skin test, TPHA, toxoplasma dye test, and chest X-ray.
    • Emphasizes that uveitis is a symptom requiring a multidisciplinary diagnostic approach.
    • Highlights the need for continued research into idiopathic uveitis cases.