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Human genetics in Burma.

H Kyu, A Thu, P J Cook

    Human Heredity
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Trisomy 21 and other chromosomal abnormalities are common in Burma, differing from Asian reports. Genetic disorders, including thalassaemia and meningomyelocele, are prevalent, with low inbreeding intensity observed.

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    Area of Science:

    • Medical Genetics
    • Human Population Genetics
    • Clinical Genetics

    Background:

    • Previous studies from Asia suggested lower prevalence of trisomy 21.
    • Understanding genetic disorder frequency is crucial for public health initiatives in Burma.

    Purpose of the Study:

    • To investigate the prevalence of trisomy 21 and other chromosomal abnormalities in Burma.
    • To document the occurrence of various genetic disorders, including dominant, recessive, and X-linked conditions.
    • To assess twinning rates and the incidence of specific congenital anomalies and genetic diseases.

    Main Methods:

    • Population-based surveys to measure the intensity of inbreeding.
    • Clinical observations and data collection on chromosomal abnormalities and genetic disorders.

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  • Analysis of birth data for twinning rates and specific conditions like thalassaemia and meningomyelocele.

    • Main Results:

    • Trisomy 21 is common in Burma, contradicting earlier Asian reports.
    • Other chromosome abnormalities, dominant, recessive, and X-linked disorders are present.
    • Thalassaemia and meningomyelocele are relatively common; congenital dislocation of the hip and phenylketonuria are rare.
    • Twinning occurs in 1% of births (MZ and DZ equally).
    • Inbreeding coefficients (F) were low: 0.0005 in Rangoon and 0.0015 in rural Hlegu.

    Conclusions:

    • Burma exhibits a distinct pattern of chromosomal abnormalities compared to other Asian populations.
    • The study highlights the need for tailored genetic screening and healthcare strategies in Burma.
    • Low inbreeding intensity suggests other factors influence the observed genetic disorder frequencies.