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Related Experiment Videos

Plasma acute-phase reactant proteins in tuberose sclerosis.

A T Rundle

    Journal of Mental Deficiency Research
    |December 1, 1976
    PubMed
    Summary
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    Tuberous sclerosis patients often show abnormal levels of acute-phase reactant proteins. These findings may indicate the presence of neoplastic tissue and aid in genetic counseling for tuberous sclerosis.

    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Genetics

    Background:

    • Tuberous sclerosis is a genetic disorder.
    • Neoplastic tissue can trigger an acute-phase protein response.

    Purpose of the Study:

    • To investigate acute-phase reactant protein levels in tuberous sclerosis patients.
    • To explore the potential of these markers in understanding the disease and for genetic counseling.

    Main Methods:

    • Quantitative measurement of seven acute-phase reactant proteins in plasma.
    • Comparison of patient data with a control group.

    Main Results:

    • Abnormal protein levels were detected in most tuberous sclerosis patients.
    • Over 48% of subjects had abnormalities in three or more proteins.

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  • Alpha-1-antitrypsin and fibrinogen showed less significant mean differences but individual elevations were noted.

    • Conclusions:

    • Elevated acute-phase proteins in tuberous sclerosis may reflect a response to neoplastic tissue.
    • Routine biochemical monitoring could assist in genetic counseling for tuberous sclerosis.