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Purpura fulminans.

D Z Chu, F W Blaisdell

American Journal of Surgery

|March 1, 1982

Summary

This summary is machine-generated.

Purpura fulminans is a severe illness causing skin necrosis and gangrene, often linked to septicemia and disseminated intravascular coagulation. Early resuscitation and heparin are key treatments, with delayed amputation for surviving patients.

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Area of Science:

Medicine
Pathology
Immunology

Background:

Purpura fulminans is a rare, life-threatening condition.
It is characterized by widespread skin necrosis and gangrene, often affecting extremities.
Septicemia, shock, and disseminated intravascular coagulation (DIC) are common clinical features.

Observation:

The pathogenesis is thought to involve Shwartzman and Arthus reactions, though mechanisms are not fully elucidated.
Analysis of 10 patients and 58 literature cases provides insights into this condition.
Clinical presentation includes septicemia, shock, and DIC.

Findings:

Immediate resuscitation is crucial for managing shock and sepsis.
Heparin is recommended to address the DIC component.

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Management of skin necrosis resembles burn treatment, with delayed amputation advised.

Implications:

Understanding the pathogenesis of purpura fulminans can lead to improved treatment strategies.
Optimal management involves prompt supportive care and specific interventions for DIC.
Delayed surgical intervention allows for better assessment of tissue viability and potential for collateral circulation.