Related Experiment Videos
[Cardiac functional state in arterial hypertension]
Insights
Hypertensive disease impacts heart function, with cardiac pain linked to diastolic pressure and left ventricular mass. Marked hypertrophy may indicate latent heart failure, but some cases show reversible hypertrophy.
Area of Science:
- Cardiology
- Hypertension Research
- Cardiac Physiology
Background:
- Hypertensive disease is a major risk factor for cardiovascular complications.
- Understanding the relationship between hypertension and cardiac function is crucial for patient management.
- Left ventricular hypertrophy (LVH) is a common adaptation to chronic hypertension.
Purpose of the Study:
- To investigate the functional changes in the heart of patients with hypertensive disease.
- To explore the correlation between cardiac pain, hemodynamic parameters, and left ventricular mass.
- To identify indicators of latent cardiac insufficiency and the reversibility of hypertrophy in hypertensive patients.
Main Methods:
- Analysis of cardiac function in 592 patients with hypertensive disease.
- Correlation analysis of cardiac pain with diastolic arterial pressure, minute volume, and left ventricular mass.
- Assessment of intramyocardial "stress" and its relation to myocardial hypertrophy.
- Longitudinal observation (3-5 years) of hypertrophy involution in labile and stable hypertension.
Main Results:
- A significant positive correlation (r = +0.822) was found between cardiac pain and diastolic arterial pressure, minute volume, and left ventricular mass.
- Patients were categorized into "adequate" and "inadequate" hypertrophy based on intramyocardial stress.
- An inverse correlation (r = -0.78) between changes in ejection fractions and left ventricular mass during exercise suggests latent heart failure in marked hypertrophy.
- Hypertrophy involution was observed in 20/79 patients with labile hypertension and 2/27 with stable hypertension over 3-5 years.
Conclusions:
- Cardiac pain in hypertensive disease is significantly associated with hemodynamic factors and left ventricular mass.
- Marked left ventricular hypertrophy may mask latent cardiac insufficiency, particularly under stress.
- Reversibility of left ventricular hypertrophy is possible, especially in labile forms of hypertension, and is linked to changes in arterial pressure and peripheral resistance.
Abstract:
The results of studies of the function of the heart in 592 patients with hypertensive disease are reported. In 120 cases it was established that a dependence exists between the cardiac pains and the level of the diastolic arterial pressure, minute volume and the mass of the left ventricle (r = +0.822; p less than 0.01). The study of the magnitude of intramyocardial "stress" in 127 patients enabled the authors to distinguish those with "adequate" and "inadequate" hypertrophy. With submaximum exercise an inverse correlation (r = -0.78, p less than 0.01) was found to exist between the changes in the output fractions and the mass of the myocardium of the left ventricle, pointing to the latent cardiac insufficiency in patients with marked myocardial hypertrophy. Observation of 106 patients for 3-5 years has revealed hypertrophy involution in 20 out of 79 patients with the labile and in 2 out of 27 cases with a stable form of hypertension. A relationship was found to exist between the increase of the hypertrophy and the increase of the systolic arterial pressure, and between its decrease and the drop in the general peripheral resistance.