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Theophylline half-life in infants and young children
Annals of Allergy
|May 1, 1978
Insights
Theophylline elimination half-life in children aged three months to six years averaged 4.92 hours. This finding differs from prior research, with no age-related correlation observed in this pediatric cohort.
Area of Science:
- Pediatric pharmacology
- Clinical pharmacokinetics
Background:
- Theophylline is a medication used for respiratory conditions.
- Understanding its pharmacokinetic profile in children is crucial for safe and effective dosing.
Purpose of the Study:
- To investigate theophylline elimination pharmacokinetics in a pediatric population.
- To compare theophylline half-life with existing literature and assess age-related correlations.
Main Methods:
- Pharmacokinetic study involving 54 children aged three months to six years.
- Analysis of theophylline elimination half-life.
- Statistical comparison of age and half-life data.
Main Results:
- The mean theophylline elimination half-life was 4.92 hours (S.D. +/- 1.88 hours).
- This result is notably different from previously reported values.
- No significant correlation was found between age and theophylline half-life in this cohort.
Conclusions:
- The observed theophylline half-life in young children may differ from established data.
- Age does not appear to be a significant factor influencing theophylline elimination in this specific pediatric age range.
Abstract:
Pharmacokinetics of theophylline elimination were studied in a 54-child population. Subjects' ages ranged from three months to six years. The mean half life was 4.92 hours, with S.D. +/- 1.88 hours. This is at variance with previous reports. Ages and half lives were compared and there were no correlations in this young age group.