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[Local acne therapy with erythromycin].

J B Schmidt, J Thurner, C Poitscheck

    Zeitschrift Fur Hautkrankheiten
    |January 15, 1982
    PubMed
    Summary

    Topical erythromycin effectively treats papulo-pustular acne vulgaris by altering skin bacteria. The antibiotic was not detected in serum, indicating localized action for acne treatment.

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    Area of Science:

    • Dermatology
    • Microbiology
    • Pharmacology

    Context:

    • Acne vulgaris is a common skin condition.
    • Papulo-pustular acne presents therapeutic challenges.
    • Bacterial involvement in acne pathogenesis is well-established.

    Purpose:

    • To evaluate the efficacy of topical erythromycin for papulo-pustular acne vulgaris.
    • To assess the impact of topical erythromycin on the bacterial spectrum within acne lesions.
    • To determine systemic absorption of erythromycin following topical application.

    Summary:

    • Treatment of papulo-pustular acne vulgaris with a topical erythromycin preparation yielded positive results.
    • Significant alterations in the bacterial spectrum of acne lesions were observed during therapy.
    • Erythromycin was undetectable in serum samples, even after extensive topical application.

    Impact:

    • This study demonstrates the localized efficacy of topical erythromycin in managing acne vulgaris.
    • Findings support the use of topical erythromycin as a targeted therapy for acne.
    • The lack of systemic absorption suggests a favorable safety profile for topical application.

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