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Related Experiment Videos

Vaccination for fowl plague.

W K Butterfield, C H Campbell

    American Journal of Veterinary Research
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Avian influenza virus A/turkey/Oregon/71 is avirulent in chickens but induces immunity against fowl plague. This study shows it replicates and transmits early post-inoculation but remains avirulent after chicken passages.

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    Area of Science:

    • Veterinary Virology
    • Avian Pathology
    • Immunology

    Background:

    • Avian influenza viruses pose significant threats to poultry health and global food security.
    • Fowl plague virus (FPV) is a highly virulent avian influenza strain.
    • Understanding the pathogenicity and immunogenicity of different avian influenza strains is crucial for disease control.

    Purpose of the Study:

    • To investigate the pathogenicity and immunogenicity of Influenza A/turkey/Oregon/71 virus in chickens.
    • To determine the transmission dynamics and host range of this avirulent strain.
    • To assess if repeated passages in chickens alter the virus's virulence.

    Main Methods:

    • Intratracheal inoculation of chickens with Influenza A/turkey/Oregon/71 virus at various doses.

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  • Monitoring for clinical signs, antibody production, and viral shedding via tracheal swabs.
  • Transmission studies involving contact controls.
  • Serial passage of the virus in chickens for 10 generations.

    • Main Results:

    • The virus was avirulent for chickens despite having antigenic characteristics of FPV.
    • Inoculated chickens developed antibodies and immunity against fowl plague.
    • Viral replication occurred, with recovery from tracheal swabs up to 4 days post-inoculation.
    • Transmission to contact controls was observed only when cagemates were inoculated simultaneously, not 24 hours prior.
    • The virus remained avirulent for chickens and turkeys after 10 serial passages.

    Conclusions:

    • Influenza A/turkey/Oregon/71 represents a potentially valuable tool for inducing immunity against fowl plague in chickens without causing disease.
    • Early post-inoculation transmission is possible, highlighting the need for biosecurity measures.
    • The virus's avirulence is stable through multiple passages in chickens, suggesting its suitability for vaccine development or experimental studies.