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Related Experiment Videos

Hyperplastic thyroid lesions in fish.

K L Hoover

    National Cancer Institute Monograph
    |May 1, 1984
    PubMed
    Summary

    Thyroid proliferation in fish, often mistaken for goiter or cancer, is influenced by environmental factors. This study observed significant thyroid growth in guppies at 27°C but not at 17°C.

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    Area of Science:

    • Comparative endocrinology
    • Aquatic toxicology
    • Fish biology

    Background:

    • Teleost thyroids are unique, lacking a capsule and prone to ectopic placement and proliferation.
    • Environmental factors like poor water quality and nutrition can induce thyroid changes in fish.
    • Distinguishing between thyroid cancer and goiter in fish can be challenging due to these proliferative responses.

    Purpose of the Study:

    • To investigate the influence of temperature on thyroid growth in guppies (Poecilia reticulatus).
    • To review the historical controversy surrounding teleost thyroid lesions.
    • To discuss the implications of fish thyroid predisposition for carcinogenicity testing.

    Main Methods:

    • Guppies (Poecilia reticulatus) were maintained at two different temperatures: 17°C and 27°C.
    • Thyroid growth was assessed in fish from both temperature groups.
    • A review of historical data and studies on teleost thyroid proliferation was conducted.

    Main Results:

    • A marked growth of the thyroid was observed in guppies housed at 27°C.
    • No significant thyroid growth was observed in guppies housed at 17°C.
    • The study highlights temperature as a critical factor influencing thyroid proliferation in this species.

    Conclusions:

    • Temperature significantly impacts thyroid growth in guppies, suggesting an environmental predisposition.
    • The findings contribute to understanding teleost thyroid responses and their implications for toxicological assessments.
    • Further research is warranted to elucidate the mechanisms and broader significance for fish health and carcinogenicity testing.

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