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Coding strategy differences between constant and variable segments of immunoglobulin genes.

P Perrin

    Nucleic Acids Research
    |July 11, 1984
    PubMed
    Summary
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    Vertebrate immunoglobulin (Ig) gene sequences show unique codon usage patterns. Analysis reveals lower guanine + cytosine content in variable gene segments, suggesting base substitutions correlate with adenine + thymine richness.

    Area of Science:

    • Molecular Biology
    • Immunogenetics
    • Bioinformatics

    Background:

    • Vertebrate immunoglobulin (Ig) messenger RNAs (mRNAs) exhibit distinct intraspecies codon usage variations.
    • These variations differ significantly from codon usage patterns observed in yeast or bacterial genes.

    Purpose of the Study:

    • To investigate the specific patterns of codon usage variation within vertebrate immunoglobulin genes.
    • To determine the relationship between base composition and gene segments, particularly variable and constant regions.

    Main Methods:

    • Comparative analysis of available vertebrate immunoglobulin gene sequences.
    • Quantification of guanine + cytosine (G + C) content at codon position III.
    • Analysis of base substitution correlations with local nucleotide content (A + T).

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    Main Results:

    • A consistent finding of lower guanine + cytosine (G + C) content in codon position III of variable (V) segments compared to constant (C) segments.
    • An even further reduction in guanine + cytosine (G + C) content was observed in the hypervariable domains of V segments.
    • Base substitution patterns in Ig genes showed a positive correlation with local adenine + thymine (A + T) content.

    Conclusions:

    • Vertebrate immunoglobulin genes possess unique codon usage biases.
    • The observed nucleotide composition patterns suggest that base substitutions are influenced by local A + T richness within Ig gene segments.