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Cholecystitis associated with myelomatosis.

D Sherlock, B Jones

    Postgraduate Medical Journal
    |July 1, 1984
    PubMed
    Summary

    Multiple myeloma can manifest as acute cholecystitis, a gallbladder inflammation, unresponsive to standard treatment. This unusual presentation highlights myeloma

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    Area of Science:

    • Oncology
    • Immunology
    • Gastroenterology

    Background:

    • Multiple myeloma is a plasma cell malignancy impacting the immune system.
    • Myeloma commonly leads to impaired immune function, increasing susceptibility to infections.
    • Recurrent respiratory infections are the typical infectious manifestation of myeloma's immunodeficiency.

    Observation:

    • A rare case of myeloma presenting with acute cholecystitis is described.
    • The cholecystitis was refractory to conventional management strategies.
    • This presentation is atypical, as gallbladder infections are not a common myeloma complication.

    Findings:

    • The case demonstrates an unusual extraskeletal manifestation of multiple myeloma.
    • Acute cholecystitis, often caused by Gram-negative bacteria, can be a presenting symptom of myeloma.
    • Myeloma's immunosuppression may predispose patients to atypical infections like severe cholecystitis.

    Implications:

    • Clinicians should consider underlying myeloma in patients with severe, unresponsive cholecystitis.
    • This case expands the spectrum of clinical presentations for multiple myeloma.
    • Understanding myeloma-related immunodeficiency is crucial for managing diverse infections.

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