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Hepatic infarction with absolute ethanol.

D O'Riordan, H McAllister, B J Sheahan

    Radiology
    |September 1, 1984
    PubMed
    Summary
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    Ethanol effectively embolizes the hepatic artery in dogs, causing permanent arterial occlusion. This procedure, which is simple and dose-dependent, also leads to perisinusoidal fibrosis.

    Area of Science:

    • Interventional Radiology
    • Veterinary Medicine
    • Vascular Surgery

    Background:

    • Hepatic artery embolization is a therapeutic procedure.
    • Permanent occlusion of the hepatic arterial system is desirable for certain treatments.
    • Ethanol is a readily available and nonviscous agent.

    Purpose of the Study:

    • To evaluate the efficacy and permanence of ethanol-induced hepatic artery embolization.
    • To assess the histological changes following ethanol embolization.

    Main Methods:

    • Ethanol was administered to embolize the hepatic artery in 7 dogs.
    • Angiography was performed at 1 and 4 weeks post-embolization.
    • Histological examination was conducted to evaluate tissue changes.

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    Main Results:

    • Hepatic artery occlusion was achieved, proportional to the ethanol dose.
    • Angiography confirmed that embolization was permanent or more pronounced at follow-up.
    • Histological analysis revealed perisinusoidal fibrosis.

    Conclusions:

    • Ethanol is an effective and easy-to-use agent for permanent hepatic artery embolization.
    • Ethanol-induced embolization results in perisinusoidal fibrosis.