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Diffusion disk susceptibility testing with cefaclor.

S Shadomy, M Carver

    Antimicrobial Agents and Chemotherapy
    |February 1, 1978
    PubMed
    Summary
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    The experimental cefaclor disk shows improved accuracy in predicting cefaclor susceptibility compared to the standard cephalothin disk, especially for Enterococcus and Enterobacter species. Further evaluation is recommended for this new antibiotic susceptibility test.

    Area of Science:

    • Microbiology
    • Clinical Pharmacy
    • Infectious Diseases

    Background:

    • Cefaclor is a new cephalosporin antibiotic.
    • Accurate susceptibility testing is crucial for effective antibiotic treatment.
    • Standardized disk diffusion methods are widely used for antimicrobial susceptibility testing.

    Purpose of the Study:

    • To compare the reliability of the standardized cephalothin disk and an experimental cefaclor disk in predicting clinical susceptibility to cefaclor.
    • To evaluate the diagnostic accuracy of existing and novel disk diffusion methods for cefaclor.

    Main Methods:

    • Quantitative cefaclor susceptibility was determined using the World Health Organization International Collaborative Study agar dilution procedure.
    • Disk diffusion tests were performed using the standardized U.S. Food and Drug Administration disk test with both cephalothin and cefaclor disks.

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    Main Results:

    • The cephalothin disk incorrectly predicted susceptibility in 52% of Enterococcus spp. isolates resistant to cefaclor.
    • The cefaclor disk showed no such errors for Enterococcus spp.
    • For Enterobacter spp., the cephalothin disk correctly predicted susceptibility in only 20% of susceptible isolates, while the cefaclor disk achieved 70% accuracy.

    Conclusions:

    • The standardized cephalothin disk demonstrates poor reliability in predicting cefaclor susceptibility for certain bacterial species.
    • The experimental cefaclor disk shows superior performance compared to the cephalothin disk for cefaclor susceptibility testing.
    • Further evaluation of a dedicated cefaclor disk is necessary for accurate antimicrobial susceptibility testing of this new cephalosporin.