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Heparin in ultra low doses had a stabilizing effect on endothelial lining in rats. This effect was demonstrated as prevention of increases in counts of circulating endothelial cells after a standard intravenous citrate injection. The same effect of heparin was observed even with other provoking agents /adrenaline, hypotonic saline/. The duration of heparin effect was very prolonged, a 50% effect having been observed 5 hours after the administration. Subcutaneous heparin was effective only in relatively high doses and had a lower maximum effect compared with intravenous heparin.
Heparin in ultra low doses had a stabilizing effect on endothelial lining in rats. This effect was demonstrated as prevention of increases in counts of circulating endothelial cells after a standard intravenous citrate injection. The same effect of heparin was observed even with other provoking agents /adrenaline, hypotonic saline/. The duration of heparin effect was very prolonged, a 50% effect having been observed 5 hours after the administration. Subcutaneous heparin was effective only in relatively high doses and had a lower maximum effect compared with intravenous heparin.