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Updated: Jul 31, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
15:27

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Lack of behavioural teratogenic effect of phenytoin in rats

S L Cassidy, G P Rose, R W Hend

    Toxicology Letters
    |July 1, 1984
    PubMed

    A small battery of tests (static and air-righting reflexes, eye opening and a narrowing bridge test) was used to investigate the behavioural teratogenic potential of prenatal oral exposure (day 7-19 of gestation) of up to 100 mg phenytoin/kg/day to female rats. No treatment-related effects upon mother or offspring were detected. In order to validate our narrowing bridge test, neonatal old rats were tested over 4 weeks following early postnatal exposure to acrylamide (5 X 50 mg/kg/day i.p.). These animals showed a severe transient deficit compared with saline-treated controls. Despite the absence of an effect using phenytoin, the narrowing bridge test is considered worthy of further validation.

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