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Related Experiment Videos

A diagnostic "patch test" for onchocerciasis using topical diethylcarbamazine.

P Stingl, M Ross, D W Gibson

    Transactions of the Royal Society of Tropical Medicine and Hygiene
    |January 1, 1984
    PubMed
    Summary

    A new diethylcarbamazine (DEC) patch test shows promise for diagnosing onchocerciasis. This simple skin test was 92% accurate in patients in Southern Sudan, offering a potential tool for endemic areas.

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    Area of Science:

    • Tropical medicine
    • Parasitology
    • Dermatology

    Background:

    • Onchocerciasis diagnosis is challenging in resource-limited endemic areas.
    • Existing diagnostic methods often require specialized personnel and facilities.
    • There is a critical need for simple, inexpensive, and sensitive diagnostic tools.

    Purpose of the Study:

    • To evaluate the efficacy of a diethylcarbamazine (DEC) patch test for diagnosing onchocerciasis.
    • To assess the feasibility of this diagnostic approach in a field setting.

    Main Methods:

    • The DEC patch test was applied to the skin of 45 onchocerciasis patients in Southern Sudan.
    • 75 tests were performed, and reactions were recorded.
    • Histopathological examination of skin biopsies from beneath the patch was conducted.

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    Main Results:

    • The DEC patch test demonstrated a high positivity rate of 92% (69 out of 75 tests).
    • A positive reaction was characterized by a papular eruption under the patch.
    • Histopathology confirmed a severe Mazzotti reaction with degenerating microfilariae.

    Conclusions:

    • The diethylcarbamazine (DEC) patch test is a potentially simple, inexpensive, and sensitive diagnostic method for onchocerciasis.
    • This test could be valuable in endemic regions with limited resources.
    • The observed Mazzotti reaction provides histopathological evidence of test efficacy.