[Metabolism of phospholipids in various pathological states]

The composition, content and metabolic activity of phospholipids in the myocardium vary depending on the organism thyroid status as well as under conditions of alloxan diabetes. The absolute content of total phospholipids and their acid fractions (phosphatidyl serine, phosphatyl inosite and cardiolipin) are raised in rats with experimental hyperthyroidism due to intensification of their biosynthesis. In animals with hypothyroidism a decrease in the level of total phospholipids and their certain fractions (cardiolipin, phosphatidyl serine and phosphatyl inosite) correlates with the inhibition of the intensity of 32P and 3H-fatty acids incorporation into the composition of phospholipids. A sharp increase in the content of cardiolipin and a regular decrease of choline-containing lipids (phosphatidyl choline and sphingomyelin) is a characteristic feature of changes in the composition of myocardium phospholipids under experimental diabetes.