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Related Experiment Videos

The MNSs antigen Ridley (Ria).

M Contreras, S E Armitage, B Stebbing

    Vox Sanguinis
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    The low-frequency antigen Ria (Ridley) gene is closely linked to the MNSs blood group locus. This reinvestigation confirms its genetic basis within this specific kindred.

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    Area of Science:

    • * Human genetics
    • * Immunogenetics
    • * Blood group serology

    Background:

    • * The rare blood group antigen Ria (Ridley) was previously identified in a unique kindred.
    • * Its genetic inheritance pattern required further elucidation after two decades.

    Purpose of the Study:

    • * To re-examine the extended pedigree of the Ria (Ridley) antigen kindred.
    • * To determine the genetic linkage of the Ria (Ridley) antigen.

    Main Methods:

    • * Pedigree analysis of the known kindred.
    • * Serological testing.
    • * Blood group frequency studies.

    Main Results:

    • * Established that the Ria (Ridley) antigen is governed by a gene.

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  • * Demonstrated that this gene is part of or very closely linked to the MNSs blood group locus.
  • * Reported findings from further serological and frequency investigations.

    • Conclusions:

    • * The Ria (Ridley) antigen's genetic locus is confirmed to be linked to the MNSs system.
    • * Further studies provide valuable data on this rare blood group antigen.