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Related Experiment Videos

[Benign recurring intrahepatic cholestasis--a case report].

W Stremmel, T Scholten, B Miller

    Zeitschrift Fur Gastroenterologie
    |June 1, 1984
    PubMed
    Summary

    Benign recurrent intrahepatic cholestasis presents with recurring jaundice. Genetic factors are suspected, and avoiding pregnancy and oral contraceptives is advised due to potential jaundice induction.

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    Area of Science:

    • Hepatology
    • Gastroenterology
    • Internal Medicine

    Background:

    • Benign recurrent intrahepatic cholestasis (BRIC) is a rare liver disorder characterized by intermittent cholestasis.
    • Diagnosis requires excluding other causes of cholestasis and confirming intrahepatic cholestasis during episodes.

    Observation:

    • A 40-year-old female experienced seven episodes of jaundice lasting up to six months.
    • Episodes were marked by elevated conjugated serum bilirubin and alkaline phosphatase, with histological confirmation of intrahepatic cholestasis.
    • Liver function and histology normalized between episodes, and drug-induced cholestasis was ruled out.

    Findings:

    • A familial history was noted, with a sister also experiencing intrahepatic cholestasis, suggesting a probable genetic etiology.
    • The pathogenesis of BRIC remains unclear.
    • No specific treatment is available to prevent or shorten cholestatic episodes.

    Implications:

    • Patients with BRIC should avoid pregnancy and oral contraceptives, as these can trigger icteric phases.
    • Further research into the genetic basis and pathogenesis of BRIC is warranted.
    • Understanding BRIC is crucial for managing patients and providing appropriate counseling regarding disease triggers.

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