[Clinico-pharmacologic analysis neurovegetotropic activity of tranquilizers]

A comparative clinical and pharmacological analysis of the neurovegetotropic activity of the tranquilizers phenazepam and diazepam (benzodiazepine derivatives) was carried out in 287 patients with neurotic disturbances. The patients were analyzed for the genesis, structure and nature of vegetative-effector permanent and paroxysmal disorders. The regular characteristics of the interrelationship between the major psychopathological syndrome and the nature of vasovegetative dysfunctions were established. Considering the above, the differential method was used to study the therapeutic time-course of the status of patients treated with the tranquilizers. Phenazepam was shown to have a predominantly sympatheticotropic action. Comparative analysis of the therapeutic response points to a higher effectiveness of phenazepam in cases of the paroxysmal and of diazepam in cases of the permanent nature of vegetative dysfunctions.