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Estrogen-producing adrenocortical carcinoma. A light and electron microscopic study
Acta Pathologica Japonica
|May 1, 1984
Summary
This study reports a rare case of adrenocortical carcinoma in a 35-year-old man causing feminization. The tumor produced high levels of estrone (E1) and estradiol (E2), confirmed by in vitro assays.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Adrenocortical carcinoma is a rare malignancy with diverse clinical presentations.
- Feminization in men can be caused by estrogen-producing tumors.
Observation:
- A 35-year-old male presented with feminization due to adrenocortical carcinoma.
- Elevated venous blood levels of estrone (E1) and estradiol (E2) were detected.
- In vitro assays confirmed estrogen production by tumor cells.
Findings:
- Histopathological examination revealed a mixed cell population with pleomorphic and uniform cells.
- Electron microscopy showed cells with abundant mitochondria and smooth endoplasmic reticulum.
- The tumor cells exhibited characteristics of zona reticularis and fetal cortex.
Implications:
- The study highlights the correlation between the morphological features and functional properties of adrenocortical tumors.
- This case contributes to understanding estrogenic adrenocortical carcinoma.
- It underscores the importance of hormonal evaluation in feminizing adrenal masses.