Nephrotoxicity of nonsteroidal anti-inflammatory drugs

Most nonsteroidal anti-inflammatory drugs can cause a variety of adverse renal effects when used in therapeutic doses. These effects range from elevation of BUN and creatinine to renal failure. Prostaglandin inhibition and T-lymphocyte disorder are believed to be the pathogenic factors. The effects are generally reversible with discontinuance of the drug, but some patients may require supportive management with hemodialysis and therapy with immunosuppressive agents.