Related Experiment Video

Updated: Aug 9, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
05:57

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Coronary heart disease in treated hypertensive patients and risk-matched normotensive control subjects

R A Forsyth

    American Heart Journal
    |August 1, 1984
    PubMed

    Insights

    Antihypertensive therapy may not significantly reduce coronary heart disease (CHD) in hypertensive men, and shows no benefit for women. Further research is needed to confirm effects of blood pressure treatment on cardiovascular health.

    Area of Science:

    • Cardiology
    • Hypertension Research
    • Epidemiology

    Background:

    • Coronary heart disease (CHD) remains a leading cause of mortality globally.
    • Hypertension is a major modifiable risk factor for CHD.
    • The effectiveness of antihypertensive therapy in reducing CHD incidence requires ongoing investigation.

    Purpose of the Study:

    • To prospectively assess the incidence of coronary heart disease (CHD) in treated hypertensive patients compared to normotensive controls.
    • To determine if antihypertensive therapy influences CHD rates based on predicted risk.
    • To investigate potential sex-based differences in the treatment effect of antihypertensive therapy on CHD.

    Main Methods:

    • Prospective cohort study involving 543 participants (335 hypertensive, 208 normotensive controls).
    • Individual matching of controls to hypertensive subgroup based on seven risk factors.
    • Comparison of observed CHD incidence against rates predicted by initial and post-treatment blood pressure levels.

    Main Results:

    • In hypertensive men, CHD incidence aligned with post-treatment blood pressure predictions, but the reduction was not statistically significant.
    • CHD incidence in hypertensive women exceeded post-treatment predictions, with normotensive controls showing a lower-than-expected rate.
    • A potential treatment effect in hypertensive men could not be confirmed due to lack of statistical significance and similarity to control group trends.

    Conclusions:

    • Antihypertensive therapy did not demonstrate a statistically significant reduction in CHD incidence in the studied hypertensive population.
    • No evidence of a protective treatment effect was found in hypertensive women.
    • Sex-specific differences in response to antihypertensive therapy regarding CHD incidence warrant further investigation.

    More Related Videos

    Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

    Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

    Published on: June 6, 2025

    Related Concept Videos

    Hypertension and Regulation of Blood Pressure01:18

    Hypertension and Regulation of Blood Pressure

    Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
    Coronary Artery Disease IV: Preventive Measures01:26

    Coronary Artery Disease IV: Preventive Measures

    Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
    Hypertension I: Introduction01:28

    Hypertension I: Introduction

    Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
    Hypertension II: Pathophysiology01:29

    Hypertension II: Pathophysiology

    Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
    Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

    Hypertension III: Clinical Manifestations and Diagnostic Studies

    Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
    Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

    Hypertension IV: Drug Therapy and Lifestyle Modifications

    Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...