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Evaluation of total artificial heart performance in man
The American Journal of Cardiology
|August 1, 1984
Summary
This study evaluated total artificial heart (TAH) performance in its first human implant. The TAH supported circulation for 112 days, showing consistent but unequal ventricular outputs, suggesting mitral regurgitation.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Clinical Hemodynamics
Background:
- The development of total artificial hearts (TAH) is crucial for end-stage heart failure treatment.
- Evaluating TAH performance in human implants is essential for refining device function and patient management.
Purpose of the Study:
- To assess the operational characteristics and circulatory response of a TAH during its first human implantation.
- To analyze hemodynamic parameters and ventricular function over a 112-day survival period.
Main Methods:
- Performance evaluation of a TAH in the first human implantation.
- Hemodynamic monitoring including pressures, heart rate, cardiac output, and atrial pressures.
- Cineradiography and drive line analysis to assess ventricular filling and ejection.
Main Results:
- The patient survived 112 days with the TAH.
- Left-sided cardiac output was consistently higher than right-sided cardiac output.
- Cineradiography indicated complete filling but partial ejection of the right ventricle, with V waves suggesting mitral regurgitation.
Conclusions:
- The TAH demonstrated sustained circulatory support for 112 days.
- Observed differences in ventricular output may be attributed to mitral regurgitation.
- Further investigation into right ventricular function and potential valvular issues is warranted.