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Pyloric stenosis and maternal Bendectin exposure.

P Aselton, H Jick, S J Chentow

    American Journal of Epidemiology
    |August 1, 1984
    PubMed
    Summary

    Maternal Bendectin use during pregnancy may increase the risk of infantile hypertrophic pyloric stenosis. Higher Bendectin prescription numbers correlated with a greater risk for this infant condition.

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    Area of Science:

    • Pediatric Health
    • Obstetrics and Gynecology
    • Pharmacoepidemiology

    Background:

    • Infantile hypertrophic pyloric stenosis (IHPS) is a congenital disorder requiring surgical correction.
    • Understanding potential environmental or medication-related risk factors for IHPS is crucial for prevention and early intervention.

    Purpose of the Study:

    • To investigate the association between maternal Bendectin use in the first trimester and the development of IHPS in infants.
    • To explore if the dosage or frequency of Bendectin exposure influences the risk of IHPS.

    Main Methods:

    • A retrospective cohort study was conducted using data from Group Health Cooperative of Puget Sound.
    • Infants diagnosed with pyloric stenosis between 1977 and 1982 were identified.
    • Maternal pharmacy records were analyzed to determine Bendectin exposure during the first trimester of pregnancy.

    Main Results:

    • A risk ratio of 2.5 (95% CI 1.2-5.2) was observed for IHPS in infants whose mothers used Bendectin during pregnancy.
    • A dose-response relationship was found: women with five or more Bendectin prescriptions had a relative risk of 7.6 (95% CI 4.9-11.6) compared to non-exposed mothers.
    • Women with one Bendectin prescription had a relative risk of 1.2 (95% CI 0.4-4.4).

    Conclusions:

    • Maternal Bendectin use during the first trimester of pregnancy is associated with an increased risk of infantile hypertrophic pyloric stenosis.
    • The risk of IHPS appears to be dose-dependent, with higher Bendectin exposure correlating with a greater risk.
    • Further research may be warranted to confirm these findings and explore underlying mechanisms.

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