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Two unusual strains of Candida arthritis
Abstract:
Candida arthritis is an uncommon cause of infectious arthritis that may occur in seriously ill or immunosuppressed patients. This report describes two patients, one who developed Candida tropicalis arthritis and another patient who developed C. parapsilosis arthritis. One patient developed nephrogenic diabetes insipidus secondary to amphotericin B therapy and was successfully treated with intravenous miconazole. The other was unsuccessfully treated with both intraarticular and intravenous amphotericin B.
Insights
This study highlights rare cases of Candida arthritis in vulnerable patients. Effective treatment varied, with miconazole succeeding where amphotericin B failed in one case.
Area of Science:
- Infectious Diseases
- Rheumatology
- Mycology
Background:
- Candida arthritis is a rare form of infectious arthritis.
- It predominantly affects critically ill or immunocompromised individuals.
Observation:
- This report details two cases of Candida arthritis.
- One patient had Candida tropicalis arthritis, the other had Candida parapsilosis arthritis.
Findings:
- One patient developed nephrogenic diabetes insipidus due to amphotericin B treatment.
- Intravenous miconazole successfully treated this patient.
- The second patient did not respond to intraarticular or intravenous amphotericin B.
Implications:
- Treatment outcomes for Candida arthritis can be variable.
- Alternative antifungal agents like miconazole may be effective when amphotericin B fails.
- Further research into optimal Candida arthritis treatment is warranted.