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Organotin implications in anticarcinogenesis. Effects of several organotins on tumour growth rate in mice
Abstract:
Several cohorts of cancerous mice were continuously dosed with 2,2'-bipyridyl dibutyltin dichloride, 1,10-phenanthroline dibutyltin and histidine dibutyltin; presented at 1 ppm and 10 ppm in drinking water. Tumour growth rates were significantly reduced. Tributyltin fluoride (TBTF) applied dermally, using dimethyl sulfoxide (DMSO) as the carrier, over the tumour site was ineffective. Variation in thymus and spleen weight between controls and tin-exposed mice indicates a lymphatic involvement. Analysis of mouse tissue for total tin content showed high tin concentrations in the thymus and spleen.
Insights
Organotin compounds like dibutyltin derivatives significantly reduced cancerous tumor growth in mice when administered orally. However, topical tributyltin fluoride (TBTF) was ineffective, suggesting targeted delivery and compound structure are key for anti-cancer efficacy.
Area of Science:
- Toxicology
- Oncology
- Environmental Chemistry
Background:
- Organotin compounds are known for their diverse biological activities.
- Investigating the anti-cancer potential of specific organotin derivatives is crucial for therapeutic development.
- Understanding the toxicological profile and efficacy of different organotin compounds is essential.
Purpose of the Study:
- To evaluate the anti-cancer efficacy of selected organotin compounds in a murine cancer model.
- To assess the impact of oral versus dermal administration routes on tumor inhibition.
- To investigate potential lymphatic involvement and tin accumulation in key organs.
Main Methods:
- Administration of 2,2'-bipyridyl dibutyltin dichloride, 1,10-phenanthroline dibutyltin, and histidine dibutyltin to cancerous mice via drinking water at 1 ppm and 10 ppm.
- Dermal application of tributyltin fluoride (TBTF) using dimethyl sulfoxide (DMSO) as a carrier over tumor sites.
- Monitoring tumor growth rates, assessing thymus and spleen weights, and analyzing total tin content in mouse tissues.
Main Results:
- Significant reduction in tumor growth rates observed in mice treated orally with the specified dibutyltin compounds.
- Dermal application of TBTF proved ineffective in reducing tumor size.
- Variations in thymus and spleen weights suggest lymphatic system involvement, with high tin concentrations detected in these organs post-exposure.
Conclusions:
- Oral administration of certain dibutyltin compounds exhibits significant anti-cancer activity in mice.
- The route of administration and chemical structure of organotin compounds critically influence their anti-tumor efficacy.
- Organotin exposure can lead to lymphatic system alterations and accumulation in the thymus and spleen.