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Related Experiment Videos

Does UV-A potentiate 'short contact' dithranol therapy?

H Reshad, J H Barth, C R Darley

    The British Journal of Dermatology
    |August 1, 1984
    PubMed
    Summary
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    Short contact dithranol treatment effectively clears chronic plaque psoriasis. Combining it with ultraviolet-A (UV-A) light showed no added benefit in clearing psoriatic lesions.

    Area of Science:

    • Dermatology
    • Phototherapy
    • Pharmacology

    Background:

    • Chronic plaque psoriasis is a common inflammatory skin condition.
    • Dithranol and UV-A are established treatments for psoriasis.
    • Short contact therapy minimizes dithranol side effects.

    Purpose of the Study:

    • To evaluate the efficacy of short contact dithranol therapy for chronic plaque psoriasis.
    • To determine if ultraviolet-A (UV-A) irradiation enhances dithranol treatment outcomes.

    Main Methods:

    • Ten patients with chronic plaque psoriasis participated.
    • Dithranol was applied daily to psoriatic plaques on both sides of the body at increasing concentrations.
    • One side received daily UV-A irradiation, while the other served as a control.

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    Main Results:

    • No significant difference in the rate of lesion clearance was observed between the UV-A treated side and the control side.
    • Short contact dithranol treatment demonstrated effectiveness in clearing psoriatic plaques.

    Conclusions:

    • Short contact dithranol therapy is an effective treatment for chronic plaque psoriasis.
    • The addition of UV-A irradiation does not appear to enhance the clearance rate of psoriatic lesions when used with short contact dithranol.