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Related Experiment Videos

Fibronectin C in acute leukaemia.

J T Reilly, M J Galloway, M J Mackie

    British Journal of Haematology
    |September 1, 1984
    PubMed
    Summary

    Fibronectin C (FN:C), a complex of fibronectin and plasma proteins, was detected in 79% of acute leukemia patients at diagnosis. This biomarker disappeared upon remission and reappeared upon relapse, suggesting its potential role in monitoring leukemia.

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    Area of Science:

    • Hematology
    • Clinical Chemistry
    • Immunology

    Background:

    • Fibronectin C (FN:C) is a complex of fibronectin with other plasma proteins.
    • Its detection is typically performed using crossed two-dimensional immunoelectrophoresis.
    • FN:C has not been consistently observed in normal plasma samples.

    Purpose of the Study:

    • To investigate the presence and clinical significance of FN:C in patients with acute leukemia.
    • To determine the correlation of FN:C levels with disease status, chemotherapy response, and relapse.
    • To explore the potential composition and relationship of FN:C with fibrinogen/fibrin.

    Main Methods:

    • Crossed two-dimensional immunoelectrophoresis was employed to detect FN:C.
    • Plasma samples were analyzed from patients with acute leukemia at diagnosis and during chemotherapy.
    • Coagulation activation markers were assessed in FN:C positive and negative patients.

    Main Results:

    • FN:C was detected in 79% of acute leukemia patients at diagnosis.
    • FN:C persisted during chemotherapy and disappeared upon complete remission in most patients.
    • FN:C reappeared in a patient with relapsed leukemia, and was present in both acute lymphoblastic and non-lymphoblastic leukemia.
    • Remission rates were comparable between FN:C positive and negative patients.
    • Evidence suggests FN:C composition relates to fibrinogen/fibrin binding to fibronectin.

    Conclusions:

    • FN:C is a potential biomarker for acute leukemia, indicating its presence at diagnosis and its dynamic changes during remission and relapse.
    • The composition of FN:C may involve fibrinogen/fibrin interactions with fibronectin.
    • FN:C presence does not appear to correlate with in vivo coagulation activation or overall plasma fibronectin levels.

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