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Ciliary muscle dysfunction in Adie's syndrome.

R A Bell, H S Thompson

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |April 1, 1978
    PubMed
    Summary
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    Adie's syndrome often involves ciliary muscle dysfunction, leading to accommodative paresis that tends to recover over time. Pilocarpine testing revealed supersensitivity, aiding in Adie's syndrome diagnosis.

    Area of Science:

    • Ophthalmology
    • Neuro-ophthalmology

    Background:

    • Adie's syndrome is characterized by tonic pupils and impaired accommodation.
    • Ciliary muscle dysfunction is a key feature, though not always fully understood.

    Purpose of the Study:

    • To investigate ciliary muscle function in Adie's syndrome patients.
    • To identify potential diagnostic aids for Adie's syndrome.

    Main Methods:

    • Retrospective and prospective study of 139 patients with Adie's syndrome.
    • Clinical history, assessment of accommodation, and pilocarpine supersensitivity testing.

    Main Results:

    • Two-thirds of patients reported ciliary muscle-related symptoms.
    • Moderate accommodative paresis was common, with a tendency for recovery.

    Related Experiment Videos

  • One-third developed induced astigmatism, possibly due to segmental ciliary muscle paralysis.
  • 73% showed ciliary muscle supersensitivity to pilocarpine, suggesting a diagnostic utility.
  • Two cases presented with bilateral ciliary muscle dysfunction and unilateral pupillary abnormalities, possibly 'pupil-sparing' Adie's syndrome.

    • Conclusions:

    • Ciliary muscle dysfunction is prevalent in Adie's syndrome, often improving with time.
    • Pilocarpine supersensitivity testing can be a valuable diagnostic tool.
    • The study identified potential variations in Adie's syndrome presentation, including bilateral ciliary muscle issues.